But long term use of these drugs, which include ibuprofen, diclofenac and naproxen, often causes serious digestive problems, with up to 30 per cent of patients developing peptic ulcers.

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5 mg day and 15 mg day, was comparable to piroxicam 20 mg day and diclofenac sr 100 mg day and consistent with the efficacy seen in the u.

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systemic clearance of diclofenac from plasma is 263 56 ml min mean sd .

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the mechanism of action of diclofenac, like that of other nsaids, is not completely understood but involves inhibition of cyclooxygenase cox-1 and cox-2 .

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may have the side effects of diclofenac are gi upset-ulcers, bleeding or even gi perforation.

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